Jul 1, 2014 · T cells undergo distinct metabolic reprogramming events upon activation and differentiation to inflammatory effectors or regulatory cells. Macintyre et al. show that Glut1 is …

Jul 1, 2014 · CD4 T cell activation leads to proliferation and differentiation into effector (Teff) or regulatory (Treg) cells that mediate or control immunity. While each subset prefers distinct …

Jun 12, 2014 · CD4 T cell activation leads to rapid proliferation and differentiation into effector (Teff) or regulatory (Treg) cells that mediate or control immunity. While Teff and Treg prefer …

CD4 T cell activation leads to proliferation and differentiation into effector (Teff) or regulatory (Treg) cells that mediate or control immunity. While each subset prefers distinct glycolytic or …

Treg cells, in contrast, were enriched in vivo and appeared functionally unaffected and able to suppress Teff, irrespective of Glut1 expression. These data show a selective in vivo …

Jan 22, 2015 · It requires a series of complex and coordinated signals to drive the activation, proliferation, and differentiation of appropriate T cell subsets. It is now established that …

Supporting: 35, Contrasting: 3, Mentioning: 937 - SUMMARY CD4 T cell activation leads to rapid proliferation and differentiation into effector (Teff) or regulatory (Treg) cells that mediate or …

In this context, key fl enzymes and various glycolytic intermediates, in conjunction with transcription factors and cytokines, play a crucial role in CD4 + T cell differentiation and function.

A genetic INTRODUCTION approach is needed to establish the cell-intrinsic roles of glucose metabolism in T cell activation and regulation of inflammation. T cell activation initiates a …

Sep 11, 2019 · An increasing body of evidence indicates that bio-energetic metabolism of T cells can be manipulated to control T cell responses. This potentially finds a field of application in …