Aromatase is localized in the endoplasmic reticulum where it is regulated by tissue-specific promoters that are in turn controlled by hormones, cytokines, and other factors.

Nov 25, 2025 · Aromatase, also known as estrogen synthase, is an enzyme that plays a central role in regulating the balance of sex hormones. It is a cytochrome P450 enzyme encoded by the CYP19A1 …

Aromatase is also called estrogen synthetase or estrogen synthase, highlighting its primary role in estrogen biosynthesis. It is involved in the final steps of creating estrogens, a class of steroid hormones.

In both sexes, aromatase is found in a number of extragonadal sites, including bone, breast, adipose tissue and brain. This tissue-specific expression of aromatase maintains tight local control over the …

Mutations in the aromatase gene (CYP19A1) can result in a lack of aromatase activity and, as a consequence, impairment in estrogen biosynthesis. The functional consequences of this deficiency …

Aromatase is responsible for turning female androgen and male testosterone into estrogen. Its main function may be to keep a balance between active amounts of cortisol and active amounts of …

Aromatase (estrogen synthetase; EC 1.14.14.1) catalyzes the demethylation of androgens' carbon 19, producing phenolic 18-carbon estrogens. Aromatase is most widely known for its roles in reproducti...

Aromatase is an enzyme that plays a crucial role in the biosynthesis of estrogens from androgens. It is responsible for the conversion of testosterone and androstenedione into estradiol and estrone, …

Dec 13, 2025 · Aromatase is well recognized for its role in estrogen synthesis; however, most research to date has focused on neuronal aromatase, leaving its astrocyte-specific functions, such as …

Jan 31, 2026 · A meta-analysis by the Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) provides an important synthesis of the available randomised evidence on extended aromatase …