K Haneef, R Saleem, MSI Khan, OS Adeyinka, S Banday, MU Asghar, ... Etiology and antimicrobial resistance patterns of Extended Spectrum Beta Lactamases (ESBL) producing E. coli from urinary...

Kabeer Haneef has completed PhD (Immunology) from Tsinghua University, School of Life Sciences (SLS), Laboratory of lymphocyte signaling and Molecular Imaging. Currently working...

Targeting and modifying virus receptor binding regions to activate B cell receptors (BCRs) is a promising way to develop long-term immunity against SARS-CoV-2.

Targeting and modifying virus receptor binding regions to activate B cell receptors (BCRs) is a promising way to develop long-term immunity against SARS-CoV-2.

Jan 20, 2020 · Here, we summarize the models that have been proposed to explain BCR activation, including the cross-linking model, the conformation-induced oligomerization model, the dissociation activation model, and the conformational change model.

Sep 1, 2024 · Primary Sjögren’s syndrome (pSS) is a systematic autoimmune manifestation of the exocrine glands caused by impaired lymphocytic infiltration, leading to dry eyes and xerostomia. The pathologic hallmark of this disease is the dysfunction of the exocrine glands, which results in dry eyes and mouth.

*Correspondence: Kabeer Haneef, School of Life Science, Institute for Immunology, Tsinghua University, Beijing 100084, China. [email protected]; Rabia Saleem, Department of Pediatric Haematology, Oncology and BMT, The Children’s

Semantic Scholar extracted view of "B cell receptor (BCR) guided mechanotransduction: Critical hypothesis to instruct SARS-CoV-2 specific B cells to trigger proximal signalling and antibody reshaping" by K. Haneef et al.

Therapies targeting aberrant B-cell activation have shown promising efficacy in achieving the clinical alleviation of SLE, suggesting the discovery of new drug targets from these aberrant signaling pathways is imminent.

Aug 7, 2022 · Here, we review recent reports of a new class of isoprenoid-derived DAMPs, including farnesyl pyrophosphate and geranylgeranyl pyrophosphate, both of which are pivotal metabolic intermediates of the mevalonate pathway. We also explore the roles of old and new DAMPs in autoimmune diseases that result from dysregulated inflammation.