The opportunity for another signature win awaits Darian DeVries and the West Virginia Mountaineers this Saturday as they get set to host No. 2 Iowa State inside the WVU Coliseum. WVU has lost just one time this season at home,

Top-ranked teams in the Big 12 meet. We continue our College Basketball odds series with a Iowa State-West Virginia prediction and pick.

WVU has undergone a massive defensive turnaround under new head coach Darian DeVries. The Mountaineers are 10th in the country in 3-point defense (28.1%) and should limit a Houston squad that shoots a sizzling 41.5% from deep.

Iowa State has lost its last eight games at West Virginia and is 2-9 there all-time. The Cyclones have outscored Big 12 foes by an average of 14 points per game. WVU is coached by Darian DeVries, who left Drake in March. He was 150-55 over six seasons at Drake, and led the Bulldogs to three NCAA tournament appearances.

Iowa State men's basketball is back on the road, and it is searching for its first win at West Virginia since 2015. Here are three things to watch.