imageimageThe interplay between lipid droplets (LDs) and the Golgi apparatus has been well established, yet their mechanistic details and functional significance remain largely elusive. This study ...

This month's cover highlights the article Ganglioside GT1b prevents selective spinal synapse removal following peripheral nerve injury by Sung Joong Lee, Sunghoe Chang and colleagues. The image shows ...

To attribute disease to cell type, and molecular features of cells to disease state, we need to define and distinguish cell types, subtypes and states (Dann et al, 2023).We follow others (Fleck et al, ...

Hormone receptor-positive (estrogen receptor-positive (ER+) and/or progesterone receptor-positive (PR+)) breast cancer constitute 70–80% of breast malignancies (Rozeboom et al, 2019).In ER+ breast ...

Genomic and epigenomic patterns within DNA molecules are pivotal for a broad spectrum of in-vitro diagnostic applications, including companion diagnostics (Fridlyand et al, 2013; Van Neste et al, 2011 ...

Recent reports provide evidence for a functional link between kinetochores and spindle bipolarization in oocytes. In mouse oocytes, NDC80, which forms a heterodimer with NUF2 and serves as a major ...

This month's cover highlights the article EGFR controls transcriptional and metabolic rewiring in KRASG12D colorectal cancer by Dana Krauß, Maria Sibilia and colleagues. The tumor-intrinsic role of ...

Neural stem cells (NSCs) in the mammalian brain decline rapidly with age, leading to impairment of hippocampal memory function in later life. However, the relationship between epigenetic remodeling ...

The intricate higher-order structure of chromatin within the cell nucleus has been extensively elucidated through the efforts of the four-dimensional nucleome (4DN) project (The 4D Nucleome Network et ...

Drosophila melanogaster is a widely used model organism in cancer research due to its genetic tractability and the high degree of conservation of key cancer-related pathways (Bilder et al, 2021; Liu ...

The Fanconi anemia (FA) pathway is a critical DNA damage response mechanism responsible for the repair of replication barriers such as interstrand crosslinks (Raschle et al, 2008), R-loops (Hodson et ...

The nucleosome is the fundamental repeating unit of chromatin in eukaryotes. In the nucleosome, two histone H2A-H2B dimers and a histone H3-H4 tetramer form the histone octamer, in which 145–147 base ...