SANTA CLARA, Calif. -- The San Francisco 49ers open the 2025 regular season against the Seattle Seahawks on Sept.7 at Lumen Field (4:05 p.m. ET).

Highlights from the Preseason Week 3 matchup between the Los Angeles Chargers and the San Francisco 49ers during the 2025 NFL ...

Rookie quarterback DJ Uiagalelei obtained the first touchdown of his young NFL career in the Chargers' preseason finale ...

Los Angeles Chargers quarterback DJ Uiagalelei's pass is snagged by San Francisco 49ers linebacker Curtis Robinson for a pick ...

There were plenty of cringeworthy performances by Chargers players hoping to make the 53-man roster, but a few players ...

The Los Angeles Chargers completed their extensive, four-game preseason riddled with injury bugs and final roster competition ...

SANTA CLARA, Calif. — Trey Lance's return to the Bay Area led to three straight punts for the Los Angeles Chargers, who went ...

Finally, the preseason has come to a conclusion for the San Francisco 49ers. They ended it with a 30-23 win against the Los ...

Late in the fourth quarter, wide receiver Luke Grimm muffed the punt, and it was recovered by the 49ers at the Chargers' ...

San Francisco 49ers wide receiver Junior Bergen muffs punt and cornerback Nikko Reed recovers to take over in 49ers' red zone ...

The San Francisco 49ers continue to suffer horrible injury luck, as offensive tackle Isaiah Prince went down in the fourth ...

San Francisco 49ers linebacker Nick Martin punches the ball to force a fumble, and defensive lineman Evan Anderson recovers ...