Oprah Winfrey discusses GLP-1 weight-loss medications and obesity as a disease, challenging long-held misconceptions about willpower and food addiction.

A new book unpacks how obesity nudges the body to store more fat, making weight loss complicated. That's something Oprah understands first hand.

The 1985 moment went from exciting to shameful for the daytime up-and-comer after the comedian shamed her

Oprah Winfrey has gone through a noticeable weight loss transformation, but in a new, informative interview, she revealed she actually gained a fairly significant amount of weight during a "test" last year.

For years, she seemed powerless against a fluctuating weight problem, until new medications, and a new attitude, gave Oprah Winfrey a breakthrough. She talks with Jane Pauley about "Enough," a new book co-written with Dr.

Oprah Winfrey uncovered the exact number on the scale that ignited her weight-loss journey. During the Tuesday, January 13, episode of TODAY With Jenna & Sheinelle, the media legend, 71, described what her “enough point” was.

The longtime friends shared laughs and hard truths during a 92Y event centered on obesity, health, and Winfrey’s new book

Oprah Winfrey ffers Sheinelle Jones advice as she embarks on a new chapter as co-host of TODAY with Jenna & Sheinelle.

The talk show queen, who does not shy away from talking about her love of GLP-1 medications like Ozempic and Wegovy, dropped about 50 pounds after going on the drug two and a half years ago, but then quickly gained back 20 pounds when she stopped taking it.

Oprah Winfrey revealed she accepted jokes about her weight because she felt she deserved them, sharing her journey of shame and self-blame in a candid interview on "The View."

Oprah Winfrey has been friends with former first couple Barack and Michelle Obama for many years now. Here's a look inside their lasting connection.