Two novel agents targeting angiopoietin-like protein 3 demonstrated safety and lipid-lowering capabilities in phase 2 trials, ...

How alterations in cell metabolism translate into specific developmental gene programs remains a major question. This study ...

Obesity and related metabolic disorders, such as hyperlipidemia and non-alcoholic fatty liver disease, have become ...

BPGbio, Inc., a leading biology-first, AI-powered clinical-stage biopharma company focused on mitochondrial biology and protein homeostasis, today announced the presentation of seven presentations at ...

This important study shows that nutrient stress emanating from the microenvironment induces metabolic vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). Using a combination of cell-based and ...

Mitochondria play a crucial role in acquiring pluripotency and determining cell fate. The mitochondrial unfolded protein ...

They also found that lipids redirect metabolism to the serine ... increased the antioxidant glutathione, which reduces reactive oxygen species molecules and, therefore, promotes the survival ...

Overall, the claims of the authors are supported by solid evidence. The work should be of interest to both basic and medical biologists working on lipid metabolism.

Cholesteryl esters (CEs) and triacylglycerols (TAGs) are stored in lipid droplets (LDs), but their compartmentalisation is not well understood. Here, we established a hyperspectral stimulated Raman ...

Intriguingly, these findings point to the possibility that aerobic metabolism may have occurred long before the evolution of oxygenic photosynthesis. Evidence suggests that the earliest aerobic ...

Researchers at Baylor College of Medicine showed that lipid accumulation in tumor cells ... our field has focused on the role of fatty acid metabolism in regulating the immune response and ...