Many learners are more facile with the use of large language models in medicine than their supervisors are. The authors ...

The FDA has begun soliciting feedback to inform the next version of the Prescription Drug User Fee Act. User fees remain ...

A small-molecule drug proves its mettle in the treatment of spinal muscular atrophy, a disease amenable to intervention at the pre-mRNA level.

A man from rural India presented with redness and blurry vision in one eye. Examination was notable for panuveitis and a live worm in the posterior segment; the worm was removed in a pars plana vit ...

A 28-year-old woman was admitted to the hospital because of severe hypoxemia and right heart failure that had been caused by rapidly progressive pulmonary hypertension. A diagnosis was made.

An industry-supported center claims that it costs companies $2.6 billion to develop a new drug. But we need a broader-based and more transparent reckoning of research-and-development costs to infor ...

An 80-year-old woman presented with a 3-day history of abdominal pain. Imaging revealed numerous small gallstones in the gallbladder and cystic duct, consistent with cholecystitis.

A 72-year-old woman with a 30-year history of paraplegia was referred to the urology clinic for treatment of a bladder stone. CT of the abdomen revealed a large bladder stone with a tree ring ...

Neoadjuvant trials introduce new drugs preoperatively in patients with localized breast cancer, using the rate of pathological complete response as the primary end point. The FDA has issued guidanc ...

The author describes the scientific foundations of a clinical trial of a first-in-class small-molecule estrogen receptor degrader to treat patients with metastatic breast cancer.

A 55-year-old man in the ICU had a sudden-onset vesicular rash appear across his trunk and arms. On examination, he was febrile and had clear vesicles resembling water droplets across his torso (sh ...

Thinking of “culture” as a process in which tensions between social values are resolved, rather than as a fixed state, may help U.S. health care leaders envision an approach to transforming ...