Multiple positions of cholesterol as it translocates through the common pathway, including the off-pathway intermediate. (a) upright ( δ) (b) tilted ( γ) (c) overtilted ( E ), the off pathway ...

This study is valuable for understanding how dysfunctional mitochondria contribute to vascular diseases by investigating the influence of Miro1 on smooth muscle cell proliferation and neointima ...

Shot can act as a molecular linker between microtubules and actin during dendrite pruning, suggesting an intriguing role in non-centrosomal microtubule organization. However, the experimental evidence ...

This leads them to conclude that “subjective measures do not reliably measure the construct they intend to measure” and that their construct validity is threatened. Here, we argue that the main ...

This study should be of interest to the communities working on cell metabolism and on host-pathogen interactions. Viral infection begins with attachment to host surface structures such as receptors, ...

The ROOT & SHOOT project in the plant sciences has produced guidelines to help scientific societies organize conferences that are more inclusive and offer more supportive environments to all attendees ...

This study presents valuable computational findings on the neural basis of learning new motor memories and the savings using recurrent neural networks. The evidence supporting the claims of the ...

This study presents a valuable comparison of the efficiency and precision of two prime editing methods to introduce single-nucleotide variants and longer exogenous DNA sequences into the zebrafish ...

Reviewer #1 (Public review): Summary: The crystal structure of the Sld3CBD-Cdc45 complex presented by Li et al. is a significant contribution that enhances our understanding of CMG formation during ...

This valuable paper describes the crystal structure of a complex of the Sld3-Cdc45-binding domain (CBD) with Cdc45, which is essential for the assembly of an active Cdc45-MCM-GINS (CMG) double-hexamer ...

Identification of the trail-following pheromone receptor in the termite Prorhinotermes simplex represents the first functional characterization (deorphanization) of an odorant receptor in termites.

Figure 1. Sld3CBD–Cdc45 complex structure (A) Structure of the Sld3CBD–Cdc45 complex. Sld3CBD and Cdc45 are colored in green and magenta, respectively. Cdc45-binding parts α8CTP and α9 are labelled ...