San Francisco 49ers running back Isaac Guerendo (knee, ankle) exited during the first quarter of Sunday's Week 18 game ...

San Francisco 49ers RB Isaac Guerendo was carted off the field in Week 18's matchup against the Arizona Cardinals. He has ...

Rookie running back Isaac Guerendo was carted off the field early in the 49ers’ season finale in Arizona against the ...

Rookie running back Isaac Guerendo was carted off the field early in the 49ers’ season finale in Arizona against the Cardinals with a leg injury.

San Francisco 49ers running back Isaac Guerendo was carted off the field in the first quarter against the Arizona Cardinals.

San Francisco running back Isaac Guerendo was injured and carted off early during the 49ers' season finale versus the Arizona ...

The 49ers have running backs Christian McCaffrey (knee), Elijah Mitchell (hamstring) and Jordan Mason (ankle) on injured reserve, which elevated Guerendo to the starting role Dec. 8. They have started ...