Brock Purdy's career-high five touchdown passes kept the 49ers in the hunt to claim the NFC's top seed. Cooper Neill / Getty Images Brock Purdy threw a career-high five touchdown passes, and the San ...

San Francisco 49ers tight end George Kittle is dealing with a “mid-to-low ankle sprain,” according to ESPN’s Jeremy Fowler, after Kittle said postgame he believed he avoided a high ankle sprain, and ...

INDIANAPOLIS – Here is how the 49ers (11-4) graded in Monday night’s 48-27 win over the host Colts (8-7): PASS OFFENSE: A Brock Purdy threw a career-high five touchdown passes, including three on the ...

The San Francisco 49ers look like they're getting hot at the right time. San Francisco beat the Indianapolis Colts 48-27 on Monday night for its fifth straight game. The 49ers are 11-4 and remain a ...

Two of the NFL's best headlined a Week 16 matchup with playoff implications, as Christian McCaffrey and the San Francisco 49ers defeated Jonathan Taylor and the Indianapolis Colts, 48-27, at Lucas Oil ...

INDIANAPOLIS -- The 49ers just beat the Indianapolis Colts 48-27 and won their 11th game of the season. Last season, they lost 11 games. Which means there's something different and special about this ...

In the final game of what has been a wild Week 16, the Indianapolis Colts host the San Francisco 49ers on "Monday Night Football." The Colts come into this game starting 44-year-old Philip Rivers at ...

Our NFL experts have readied their 49ers vs. Colts predictions and best bets for Monday Night Football! From the spread and total to player props and anytime TD predictions, our NFL picks have got you ...

The Seattle Seahawks looked like a team that didn’t trust its quarterback. They were running the ball in situations perceived as passing. Sam Darnold threw two costly interceptions when Seattle let ...

George Kittle exited Week 16 game with an ankle injury, questionable to return. Before injury, Kittle had 7 catches, 115 yards, 1 touchdown, first 100-yard game of season. San Francisco 49ers won ...

The San Francisco 49ers will play the Indianapolis Colts for Monday Night Football. The Week 16 game is scheduled for 8:15 p.m. on Monday, Dec. 22, 2025. Viewers can watch the game on ESPN or stream ...