The FDA has begun soliciting feedback to inform the next version of the Prescription Drug User Fee Act. User fees remain ...

The landscape for genetically modified organisms is changing, thanks to sharp increases in the amounts and numbers of chemical herbicides applied to GM crops and the classification of two of the mo ...

The benefits of women’s health research haven’t been limited to women. But actions by the Trump administration threaten to dismantle the hard-won progress in this area.

MASLD has become the most common chronic liver disease worldwide. The authors review the features of the disease as well as pharmacotherapies targeting the associated liver and cardiovascular ...

A small-molecule drug proves its mettle in the treatment of spinal muscular atrophy, a disease amenable to intervention at the pre-mRNA level.

A 28-year-old woman was admitted to the hospital because of severe hypoxemia and right heart failure that had been caused by rapidly progressive pulmonary hypertension. A diagnosis was made.

A man from rural India presented with redness and blurry vision in one eye. Examination was notable for panuveitis and a live worm in the posterior segment; the worm was removed in a pars plana vit ...

An 80-year-old woman presented with a 3-day history of abdominal pain. Imaging revealed numerous small gallstones in the gallbladder and cystic duct, consistent with cholecystitis.

Thinking of “culture” as a process in which tensions between social values are resolved, rather than as a fixed state, may help U.S. health care leaders envision an approach to transforming ...

Neoadjuvant trials introduce new drugs preoperatively in patients with localized breast cancer, using the rate of pathological complete response as the primary end point. The FDA has issued guidanc ...

The author describes the scientific foundations of a clinical trial of a first-in-class small-molecule estrogen receptor degrader to treat patients with metastatic breast cancer.

A 55-year-old man in the ICU had a sudden-onset vesicular rash appear across his trunk and arms. On examination, he was febrile and had clear vesicles resembling water droplets across his torso (sh ...