S ANTA CLARA, Calif. -- The San Francisco 49ers open the 2025 regular season against the Seattle Seahawks on Sept. 7 at Lumen Field (4:05 p.m. ET).

Finally, the preseason has come to a conclusion for the San Francisco 49ers. They ended it with a 30-23 win against the Los Angeles Chargers, spoiling Trey Lanc

Trey Lance's return to the Bay Area led to three straight punts for the Los Angeles Chargers, who went on to lose 30-23 Saturday night to the San Francisco 49ers in the final exhibition game for both teams. Curtis Robinson returned a interception of DJ Uiagalelei 32 yards for the go-ahead touchdown with 6:06 remaining to give San Francisco the win.