Chargers vs. 49ers game will air on CBS Los Angeles. It can also be streamed on NFL+ for subscribers. Streaming options for the game include the ESPN app, ESPN Unlimited and Fubo, which offers a free trial. The game will begin at 8:30 p.m. ET / 5:30 p.m. PT.

According to ESPN's Nick Wagoner, the 49ers floor is 7-10 and its ceiling is 12-5. ESPN cited its youth movement as the 49ers' biggest 2025 X-factor.

Alex Smith, former NFL quarterback, has signed a multi-year contract with ESPN, enhancing his role as a football analyst. He will appear on Sunday NFL

Kaepernick, who is still trying to play in the NFL in 2025, suited up for the San Francisco 49ers from 2011 to 2016. In 2016, he ignited a national debate by kneeling during the U.S. national anthem to protest systemic racism and police brutality.

The San Francisco 49ers are fresh off an injury-plagued 2024 campaign that saw just six wins and a last-place finish in the normally competitive NFC West. With the return of defensive coordinator Robert Saleh,

Injuries continue to pile up for the San Francisco 49ers, and the wide receiver group has once again taken a hit. According to ESPN's Adam Schefter, wide receiver Russell Gage has suffered a sprained MCL and is expected to miss seven to 10 days.

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In 2016, San Francisco 49ers quarterback Colin Kaepernick knelt during the National Anthem before a preseason game against the Green Bay Packers in protest of racial injustice and police brutality. The response to this was his jersey becoming the top-selling among NFL players at the start of the