Their approach combined two levels of data: interactions between single zinc fingers and DNA, and between each zinc finger and its neighbouring finger. These zinc finger pair interactions influence ...

Zinc is “the Barry Manilow of heavy metals—really dull and really boring. It’s not fancy, like iron or copper.” But as Adrian Woolfson, BM BCh PhD, reaches his first-year anniversary as Sangamo’s ...

Since zinc fingers are typically linked together to recognize longer DNA stretches, the team assembled them into arrays, creating new junctions between the individual zinc finger units. But there was ...

Researchers are using minute, naturally occurring proteins called zinc fingers to engineer T-cells to one day treat AIDS in humans. Using the zinc fingers, scientists have shown that they could reduce ...

BRISBANE, Calif. & BOSTON--(BUSINESS WIRE)--Sangamo Therapeutics, Inc. (Nasdaq: SGMO), a clinical-stage genomic medicine company and Chroma Medicine, Inc. (Chroma), a genomic medicine company ...

Novartis is the latest big drug firm to strike a collaboration with Sangamo Therapeutics. The two firms will develop therapies based on Sangamo’s zinc finger technology that targets genes linked to ...

RNA-binding proteins use a dual binding mechanism involving zinc finger (ZnF) domains and intrinsically disordered regions (IDR), reports a new study from the Institute of Science, Tokyo, Japan. Using ...

DNA-binding domains with predetermined sequence specificity are engineered by selection of zinc finger modules using phage display, allowing the construction of customized transcription factors.

SARS-CoV-2, the causative agent of the ongoing coronavirus disease (COVID-19) pandemic, is spreading much more efficiently than the first zoonotic highly pathogenic coronavirus (SARS-CoV). But despite ...

Gene editing strategies, from epigenetic engineering to cell reprogramming and genetic vaccines, are accelerating the development of new therapies that awaken the immune system to treat cancer, as ...

The alternative text for this image may have been generated using AI. RRE-IIB (nucleotides 39–81 of HIV RRE with 5' GGG and 3' CCC extensions for stability) and Xenopus laevis oocyte-type 5 S rRNA ...