Parkinson's disease (PD) is an age-related, progressive, neurodegenerative condition, caused by loss of dopamine-producing neurons.

The neurotransmitter dopamine influences the activity of a wide variety of brain areas. A deficiency of this substance can have drastic consequences: The death of dopamine-producing nerve cells in the ...

In a recent study published in Progress in Neurobiology, researchers discover that the substantia nigra of individuals with Parkinson’s disease had a higher concentration of pheomelanin, as well as ...

Within the human brain, movement is coordinated by a brain region called the striatum, which sends instructions to motor neurons in the brain. Those instructions are conveyed by two pathways, one that ...

Over the past dozen years, great strides have been made in identifying mutations that cause Alzheimer (AD) and Parkinson (PD) diseases. But while familial AD cases result from mutations that impinge ...

Dopamine neurons in a part of the brain called the midbrain may, with aging, be increasingly susceptible to a vicious spiral ...

The cerebellum ("little brain") is tucked underneath the basal ganglia; it sits in the back of the skull below the cerebrum. Source: CLIPAREA l Custom media/Shutterstock Neuroscientists have unearthed ...

GPR37 is an orphan G protein-coupled receptor expressed in mammalian brain, and its insoluble aggregates are found in the brain samples of juvenile Parkinson's disease patients. We have produced a ...

The neurotransmitter dopamine influences the activity of a wide variety of brain areas. A deficiency of this substance can have drastic consequences: The death of dopamine-producing nerve cells in the ...