Switching from using metronidazole to vancomycin as the initial treatment for severe Clostridium difficile infections could have a significant effect on mortality rates, according to a study ...

For more severe initial C. diff, fidaxomicin was the most cost-effective in 2 of 3 studies. For recurrent C. diff infections, fidaxomicin proved most cost-effective in 3 of 5 studies.

TUESDAY, August 5, 2025 (HealthDay News) — C. diff, which is short for Clostridioides difficile, is a type of bacteria that ...

For C. diff — a bacterial infection that can cause severe diarrhea, colitis and even death — the therapy can break cycles of recurrence that antibiotics alone may not resolve. According to an article ...

Future Perspective Even before this antibiotic was used in a patient, it appeared to have many of the characteristics required of the ideal agent for treatment of CDI. However, only time will tell ...

For treatment of a nonsevere initial recurrence of CDI, oral metronidazole should be used, but for treatment of subsequent recurrences or more severe cases fidaxomicin may be helpful.

Pseudomembranous colitis (PMC) is an antibiotic associated severe inflammatory condition of the colon caused by an overgrowth of Clostridium difficile (C. difficile), a toxin producing bacterium.