A challenge in the computational design of enzymes is that multiple properties, including substrate binding, transition state stabilization and product release, must be simultaneously optimized, and ...

E. coli cells have now been engineered into producing large quantities of serine, which is used in detergents, tube feeding formula, and as building blocks for many important chemicals. Using the ...

A team of researchers has established a new method to measure glomerular filtration rate (GFR), a primary kidney function, by calculating the clearance of D-serine. A team of researchers led by the ...

In 2001, researchers noticed that serine—unlike other amino acids—formed a charged, eight-membered cluster during electrospray ionization mass spectrometry (Anal. Chem. 2001 DOI: 10.1021/ac010284l).

D-serine as an adjunctive treatment did not outperform placebo overall in patients with major depressive disorder (MDD), a new trial showed. However, depressive symptoms and anhedonia were ...

Serine serves as a metabolic nexus in tumors, coordinating one-carbon metabolism, nucleotide synthesis, and redox regulation. In recent years, targeting the serine metabolic pathway, particularly the ...

New serine biomarkers offer hope for early Alzheimer’s detection and intervention. Study: Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble ...

In findings that may shed light on the earliest days of evolutionary history, R. Graham Cooks and a team of Purdue chemists have reported experiments that suggest why all 20 of the amino acids that ...

A dietary supplement believed to protect against Alzheimer's disease might instead be potentially harmful to the brain, a new study warns. L-serine is an amino acid that serves many different roles in ...

Studies in mice by a Salk Institute research team have shown how altered amino acid metabolism can represent a contributing factor to diabetes-associated peripheral neuropathy. Their experiments found ...

A team of researchers led by the National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) and Osaka University established a new method to measure glomerular filtration rate (GFR), ...