In Week 5, the NFL had one early morning game in London, six 1 p.m. ET starts and four that kick off at either 4:05 p.m. ET or 4:25 p.m. ET. Who will win the four late games? Below are the betting picks against the spread for the winner, spread and total for those games.

SportsLine AI evaluated the Week 5 NFL odds and revealed its NFL predictions, NFL score predictions, and NFL betting picks for every game

Jobs (Doug Pederson) and reputations (Trevor Lawrence) are on the line for the 0-4 Jaguars. The only bright spot is this is only their second home game, and the sight of the Colts, against whom they scored 68 points in two games last season, might finally awaken this moribund offense.

Newsweek's sports betting expert offers his best ATS bets for Week 5, including Steelers vs. Cowboys on Sunday Night Football in a rematch of Super Bowl XXX.

SportsLine's model simulated Arizona Cardinals vs. San Francisco 49ers 10,000 times and made its Week 5 NFL picks, predictions and best bets

Expect Dallas to struggle against a Pittsburgh defense that ranks seventh in defensive DVOA and has the highest pass-rush grade in the NFL, per Pro Football Focus. It will be up against a Cowboys offensive line that has been suspect, especially at both tackle positions.

The NFL has one super early game in Week 5 as the Jets and Vikings play in London. Then there are seven games kicking off at 1 p.m. ET. Who are the best bets for those games in terms of the winner, the spread and the total?

We have NFL predictions for six games on Sunday afternoon, including a case for both sides of the spread on one. We’re betting two ugly unders with totals that cannot be low enough and make cases for two underdogs.

The Arizona Cardinals kickoff this afternoon against one of the best teams in the NFL. Before that though we have a plethora of NFL games, including an early in London that we have all the information for you below,