One of those, of course, was MSU, which was stunned by Middle Tennessee in 2016. Perhaps even more worrisome: A 15-seed has pulled off the giant upset in three of the past four years, with only last year’s tourney seeing all four 2-seeds make the second round.

Michigan State, the No. 2 seed, and Michigan, the No. 5 seed, were both placed in the South region by the NCAA tournament selection committee.