The endogenous pathway involves the liver synthesizing lipoproteins. TG and cholesterol ester are generated by the liver and packaged into VLDL particles and then released into the circulation.

The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins. Proteins are ...

A Rutgers biochemistry professor explains how omega-6 fatty acids found in Western diets can activate cellular growth ...

Are there key genes involved in TKI resistance in ccRCC? What mechanisms are associated with this development? A research team, led by Professor Ben Liu from the Department of Urology at the First ...

Managing the metabolism of the lipid by-products of these biosynthetic pathways is important to prevent the accumulation of membrane-disruptive lipids and to conserve the energy that is invested ...

The researchers found that 57 metabolites exhibited significant changes in TD, mainly involving amino acids and lipids. These ...

New research identifies the liver protein PTPRD as a key regulator of metabolic liver disease. Reduced levels of PTPRD disrupt glucose and lipid metabolism, promote liver fat accumulation, and impair ...

and they analyzed the role of the TGF-β signaling pathway in regulating lifespan, immunity, and lipid metabolism in ...

Differences in lipid metabolism between CLL patients and healthy individuals include reduced cholesterol uptake and impaired fatty acid synthesis. Increasing lipid uptake and synthesis in CLL ...

The investigators then demonstrated that the dysregulation of this metabolic pathway led to increased lipid peroxidation—a process that damages cellular membranes and may trigger neuronal death.