This article introduces a series of papers on new guidance for the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach. Core GRADE was produced in response to the need ...

Background: Obesity is a complex, chronic, stigmatized disease whereby abnormal or excess body fat may impair health or increase the risk of medical complications, and can reduce quality of life and ...

The synthesis incorporated the quantitatively pooled results from individual reviews and assigned GRADE certainty of evidence for each intervention type. We excluded systematic reviews with high (or ...

Frequentist network meta-analyses were performed, and the GRADE approach was used to assess the certainty of evidence. For ...

The following is a summary of “Evidence for improved glucose metrics and perinatal outcomes with continuous glucose ...

1. Compared to receiving intravenous (directly into a vein (IV)) anti-cancer therapy in hospital outpatient clinics, we are uncertain whether receiving the same therapy at home affects the management ...

This review examined whether switching to a different antipsychotic medicine, as opposed to continuing treatment with the same one, improved people's response rates, alleviated overall and specific ...

The researchers will use findings from the study, combined with the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE ... the evidence is of low to very-low certainty.