Predicting when symptoms will appear could help researchers test therapies aimed at delaying or preventing the disease.

A quick and simple blood test could help predict deadly ALS years before symptoms begin. The findings come as the US faces an ...

Months to several years before amyotrophic lateral sclerosis (ALS) symptoms arise, levels of certain blood proteins may shift ...

RAG-17 is an experimental RNA-targeting therapy designed to lower toxic SOD1 protein in people with SOD1-ALS. A six-person trial found RAG-17 was well tolerated, with no serious side effects. RAG-17 ...

On the surface, the movement disorder amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and the cognitive disorder frontotemporal lobar degeneration (FTLD), which underlies ...

Huntington’s disease and ALS both affect your muscles. But while ALS causes muscle weakness and paralysis, Huntington’s is an inherited condition that causes uncontrolled movements and psychiatric ...

A new genetic study links higher levels of specific fat molecules to increased ALS risk. Fat metabolism in the body was identified as a relevant pathway in ALS susceptibility. The scientists say ...

For almost a decade, I’ve fought for a cure for a disease I don’t even have yet. In 2018, when my mom was dying of the fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS), I learned ...

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that robs individuals of the ability to control muscle movement. Although ALS is clearly a neurologic disorder involving ...

From Lou Gehrig in 1939 to Eric Dane in 2025, celebrities have publicly dealt with what is now known as ALS for decades. Amyotrophic lateral sclerosis (ALS), also called Lou Gehrig’s disease, is a ...

Single-cell gene expression patterns in the brain motor and frontal cortex, and evidence from follow-up experiments, reveal many shared cellular and molecular similarities that could be targeted for ...

Stained motor cortex tissue from a donor with ALS (right) shows reduced amounts of the protein HLA-E (green) in the vasculature. HLA-E is thought to inhibit degradation of the Blood Brain Barrier by ...