Creating analytical tools that support the advancement of knowledge can often come about through the integration of existing information and techniques, theoretical and practical, directed toward a ...

The TAP-tag (tandem affinity purification) methodology has been effectively used for genome-wide proteomic analysis in yeast. Applications in higher eukaryotes have been hindered by the technical ...

Protein yield and ease of purification are two important criteria in choosing a system for the expression/ purification of recombinant proteins. The IMPACT (Intein Mediated Purification with an ...

Protein biomarker discovery, validation and utilization require technologies that deliver proteome insights with breadth and depth. Liquid chromatography mass spectrometry (LC-MS), the gold-standard ...

Blood is an ideal, minimally invasive sample for biomarker discovery, but its complexity might make untargeted, deep proteomics challenging. This work compares plasma proteomics approaches using both ...

Proteomics is in the middle of a transition: from an exploratory, technology-driven discipline to one increasingly defined by robustness, scale, and real-world impact. To capture how this moment is ...